Biology of Immunomodulators

Abstract

We have compared effects of Poly I:C-LC, CL 24673 and Ampligen on clearance and organ localization of radiolabelled sheep erytorocytes (SRBC); peritoneal, splenic and liver cell phagocytosis; antibody PFC responses; splenic and liver natural killer (NK) cytotoxicity; specific T cell cytotoxicity; enumeration of lymphoid cell subpopulations; macrophage antiviral activity and serum interferon levels. We have also examined the effect of these agents on resistance to herpes, Punta Toro and Banzi virus infections. All three agents tested were capable of stimulating the blood clearance (reticuloendothelial) function of mice, although the timing of stimulation varied from one drug to other. All three drugs enhanced the NK cytotoxicity and serum interferon levels, although Poly I:C-LC had most profound effect on these parameters. Keywords: Antiviral agents; Macrophages; Lymphocytes; Banzi virus; Encephalitis; Herpes; Hepatitis.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1987
Accession Number
ADA196843

Entities

People

  • Abdul Ghaffar
  • Eugene P. Mayer
  • J. D. Gangemi

Organizations

  • University of South Carolina

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animal Diseases
  • B Lymphocytes
  • Biological Sciences
  • Blood
  • Cardiovascular System
  • Cells
  • Diseases And Disorders
  • Immune System
  • Infection
  • Infectious Diseases
  • Interferon
  • Lymphatic System
  • Lymphocytes
  • Macrophages
  • Resistance
  • Virus Diseases
  • Viruses

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Virology (or Medical Virology).