Primary Screening of Potential Radioprotective Agents
Abstract
This final report summarizes one and one-half year of research involving primary screening of potential radiation protective agents. The compounds were tested in toxicity screens to determine the maximum tolerated dose (MTD) which was defined as the highest dose that produces no lethal effects. Limited available drug amounts precluded more refined testing. The second screen involved Cobalt-60 gamma radiation. The agents to be tested were injected intraperitoneally into CD1 female Swiss mice, thirty minutes prior to irradiation with either 9.0 or 9.5 Gy. The latter value was found to be the radiation LD100(30) for this mouse strain. Survival was measured and the degree of protection was determined. Dose modification factors were determined on a limited number of agents as directed by the COR.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 31, 1988
- Accession Number
- ADA196901
Entities
People
- Curtis P. Sigdestad
Organizations
- University of Louisville