Acute Oral Toxicity of Guanidine Nitrate in Rats

Abstract

Guanidine nitrate is an intermediate product in the synthesis of nitroguanidine. Nitroguanidine is a primary component of US Army triple-base propellants and is now being produced in a Government-owned contractor-operated ammunition plant. The US Army Biomedical Research and Development Laboratory (USABRDL), as part of its mission to evaluate the environmental and health hazards of military-unique propellants generated by US Army munitions- manufacturing facilities, reviewed the nitroguanidine data base and identified significant gaps in the toxicity data. The Division of Toxicology, LAIR, was tasked by USABRDL to develop a genetic and mammalian toxicity profile for nitroguanidine, related intermediates/by-products of its manufacture, and its environmental degradation products. The objective of this study was to determine the acute oral toxicity of guanidine nitrate in Sprague-Dawley rats.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1988
Accession Number
ADA196954

Entities

People

  • Carolyn M. Lewis
  • Conrad R. Wheeler
  • Don W. Korte Jr.
  • Earl W. Morgan
  • Lawrence Mullen

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Body Weight
  • Chemical Analysis
  • Databases
  • Digestive System Processes
  • Guanidine Nitrates
  • Health Services
  • Information Science
  • Ions
  • Lethal Dosage
  • Materials
  • Medical Personnel
  • Nitroguanidine
  • Propellants
  • Statistical Analysis
  • Triple Base Propellants
  • United States

Readers

  • Industrial Economics
  • Rocket Propulsion.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology
  • Biotechnology - Bioremediation