Mode of Action of Shigella Toxin: Effects of Ribosome Structure and Function

Abstract

The goals of this research contract are to examine the primary action of Shigella dysenteriae 1 toxin (Shiga toxin) as an inhibitor of eukaryotic protein biosynthesis. Two major objectives of this investigation ar designed to reveal Shiga toxin-induced changes in ribosomes structure-function relationships. These objectives are 1) to explain, in biochemical terms, the manner by which Shiga toxin enzymatically inactivates mammalian ribosomes and 2) to define the the steps of protein biosynthesis which are specifically inhibited by the toxin and similar fungus- and plant-derived toxins is to be made in regard to ribosome inactivation. It is likely that information obtained from these studies will be of value in describing the role of Shiga toxin in establishment of intestinal infections by the toxin-producing Shigella species. Keywords: Pathology; Biochemistry; Microbiology.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1987
Accession Number
ADA197063

Entities

People

  • Tom G. Obrig

Organizations

  • Albany Medical College

Tags

DTIC Thesaurus Topics

  • Acids
  • Alcohols
  • Animals
  • Biomedical Research
  • Cells
  • Chemistry
  • Contracts
  • Eukaryotes
  • Gene Expression
  • Inhibitors
  • Laboratory Animals
  • Mrna
  • Nucleic Acids
  • Proteins
  • Ribonucleic Acids
  • Sugar Alcohols
  • Trna

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Microbial Pathology