Interactions Among Drinking and Ground Water Contaminants on Renal and Hepatic Function
Abstract
The intent of this proposal is to examine the effects of selected water pollutants and their interactions with chemicals known to produce liver or kidney damage. The chemicals selected for study are either ground or surface water contaminants or are the by-products of chlorination, and hence are drinking water pollutants. The test compounds were selected on the basis of their potential for actions on the kidney or liver. The standard or reference substances to be used in these studies are known nephrotoxicants or hepato- toxicants. To examine the effects of certain drinking and ground water pollutants (monochloroacetate, dichloroacetate, dichloromaleate, etc.) on hepatic and renal function in dose-response studies with particular emphasis on low-dose and multiple-dosing protocols; To examine the effects of selected drinking and ground water pollutants in conjunction with other drinking and ground water pollutants or with substances known to be nephrotoxic and or hepatotoxic (e.g., mercuric chloride, chloroform, hexachlorobutadiene, maleic acid). Some of the interactions were of a potentiative nature and some were antagonistic. Chromate appears to enhance the nephrotoxicity of some of these test compounds. All of the studies in this report suggest an important role in the tissue non-protein sulfhydryls. Keywords: Rats.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 25, 1988
- Accession Number
- ADA197075
Entities
People
- William O. Berndt
Organizations
- University of Nebraska Medical Center