Neuron-Glia Interactions and Nervous System Homeostasis
Abstract
The research program was and continues to be directed to the functional interactions between nerve fibers and their satellite glial cell investment. The long term aim is to determine the role of the glial cell in maintenance of the ionic homeostasis of the perineural environment during resting and active neuron states, the mechanisms which glial cells and neurons use to modulate each others metabolic state and the chemical, electrical and neurohumoral communication links that exist between the axon (neuron) and its associated glial (Schwann) cells. The nervous system of the freshwater crayfish, Procambarus clarkii was the preparation of choice for most of the studies the axon has been well characterized electrically and metabolically by a number of investigators including the P.I. The glial cell investment of the crayfish medial giant axon has been partially characterized by this investigator. At the time this research program was started the crayfish was only one of two such axon-Schwann cell preparations characterized for this work. The other being a tropical squid axon Schwann cell preparation not available in this country. In latter phases of this research program the emphasis, as originally planned, was shifted to the development of a mammalian cell culture model for axon-Schwann cell interaction studies for the purpose of determining the generality of our findings in the invertebrate systems.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1988
- Accession Number
- ADA197209
Entities
People
- Edward M. Lieberman
Organizations
- East Carolina University