Platelet Activating Factor Receptor Blockade Enhances Recovery after Multifocal Brain Ischemia
Abstract
We treated four anesthetized dogs (Canis familiaris) with the platelet activating factor (PAF) receptor antagonist kadsurenone prior to 60 min of multifocal ischemia induced by air embolism, and measured neuronal recovery, blood flow and autologous Indium III labeled platelet accumulation for 4 h after ischemia. Four anesthetized animals with identical ischemia served as controls. Kadsurenone (3 mg/kg) administered 5 min prior to ischemia and continuously (1 mg/kg/hr) throughout ischemia and recovery significantly enhanced recovery of cortical somatosensory evoked response (CSER) amplitude (% of baseline) when compared to controls (27-36% vs 9-14%, p < 0.05). We estimated platelet accumulation as Indium III activity (cmp/g tissue) in the injured hemisphere minus that in the non-injured hemisphere. Kadsurenone treated animals did not exhibit significantly altered Indium III platelet accumulation when compared to controls (6158 + or - 2386 vs 9979 + or - 3852, mean + or - SEM). Beneficial effects of PAF receptor blockade other than those on platelet accumulation may be involved. Reprints.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 19, 1987
- Accession Number
- ADA197263
Entities
People
- Andrew J. Dutka
- John M. Hallenbeck
- K. K. Kumaroo
- Patrick M. Kochanek
Organizations
- Naval Medical Research Center