Elevation of Arterial Pressure in Rats by Two New Vertebrate Peptides FLFQPQRF-NH2 and AGEGLSSPFWSLAAPQRF-NH2 Which are Immunoreactive to FMRF-NH2 Antiserum

Abstract

We found that two recently characterized neuropeptides Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (F-8,F-NH2) and Ala-Gly-Glu-Gly-Leu-Ser-Ser-Pro-Phe-Trp- Ser-Leu-Ala-Ala-Pro-Gln-Arg-PheNH2 )A-18-F-NH2) elevate mean arterial blood pressure (MAP) in conscious, unrestrained rats. The pressor activities of both agents were attenuated, but not abolished, by prior treatment with guanethidine or prazosin. These results suggest that the two neuropeptides elevate MAP in rats by potentiating the release of catecholamines and by mechanisms independent of catecholamine release. Keywords: Reprints, Cardioexcitatory peptides, Central nervous system, Brain.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1987
Accession Number
ADA197266

Entities

People

  • Brian L. Roth
  • Elizabeth A. Majane
  • Hsiu-ying T. Yang
  • Jerry Disimone

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Arteries
  • Biomedical Research
  • Blood
  • Brain
  • Cardiovascular Physiological Phenomena
  • Catecholamines
  • Department Of Defense
  • Heart Rate
  • High Pressure
  • Immune Serums
  • Jugular Vein
  • Laboratory Animals
  • Liquid Chromatography
  • Materials
  • Peptides
  • Veins

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry