AFRRI (Armed Forces Radiobiology Research Institute) Reports, January, February and March 1988. First quarter 1988

Abstract

A possible mechanism by which disodium cromoglycate (DSCG) prevents a decrease in regional cerebral blood flow but not hypotension in primates following whole body gamma-irradiation was studied. Several studies have implicated superoxide radicals in intestinal and cerebral vascular disorders following ischemia and ionizing radiation, respectively, The superoxide radical is formed during radiolysis in the reaction between hydrated electrons and dissolved oxygen. For this reason, the efficiency of DSCG to scavenge hydrated electrons and possibly prevent the formation of the superoxide radical was studied. The results show that DSCG is an efficient hydrated electrons scavenger and may effectively compete with oxygen for hydrated electrons preventing the radiolytic formation of the superoxide radicals. Keywords: Disodium cromoglycate, Cromolyn, Hydrated electrons, Spin trapping, Electron spin resonance, Reprints.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1988
Accession Number
ADA197281

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  • Armed Forces Radiobiology Research Institute

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