Retinal Derived Growth Factor: A Regulator of Neural Regeneration and Revascularization in Wound Healing

Abstract

Acidic Fibroblast Growth Factor (aFGF), which is identical to Retina Derived Growth Factor (RDGF), is a growth factor that stimulates neural differentiation and the formation of neurites. Work performed under this contract is determining if a gradient of aFGF can stimulate neurites growth in the direction of increasing aFGF concentrations. Preliminary experiments establishing conditions for a slow release of aFGF over a period of several days to create such a gradient have been established. Subsequent work will determine if PC12 cells or rat sensory cells will extend neurites in response to this gradient. We are also determining if aFGF can stimulate nerve regeneration in an in vivo animal model that measures nerve regeneration in a transected siatic nerve through a nerve guide tube. These experiments are providing evidence that purified aFGF can stimulate regeneration and that this regeneration is primarily due to an increase in neurite formation by sensory nerves. Neurogenesis.

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Document Details

Document Type
Technical Report
Publication Date
Dec 22, 1987
Accession Number
ADA197299

Entities

People

  • John A. Wagner

Organizations

  • Dana–Farber Cancer Institute

Tags

DTIC Thesaurus Topics

  • Animals
  • Cells
  • Chlorides
  • Classification
  • Contracts
  • Growth Factors
  • Laboratory Animals
  • Motor Neurons
  • Nerves
  • Neurons
  • Peripheral Nervous System
  • Polymers
  • Regulators
  • Sciatic Nerve
  • Security
  • Tumor Cell Line
  • Wound Healing

Fields of Study

  • Biology

Readers

  • Neuroscience
  • Trauma Surgery or Emergency Medicine.