Effects of oligo-PGB on Inflammation and Infectious Diseases
Abstract
The results have establish in-vivo the anti-inflammatory effects of oligo-PGB(Prostaglandin B). The biochemical data, provide a fundamental understanding of how oligo-PGB can protect various cells and organ systems from injury by focusing on biochemical events at the level of the cell membrane. The in vitro studies illustrating anti-lipolytic and anti-oxidant activities of oligo-PGB, and the confirmation of these effects on cellular signal and transduction events as measured by depressed arachidonate mobilization and prostanoid formation provide a molecular basis for the anti-inflammatory and cytoprotective action of oligo-PGB. In the first series of experiments with the C57BL/6J inbred mice, Carrageenin was injected into the mouse foot pad, the second foot pad was injected with an equal volume of the vehicle only (0.9% PBS + 5% sodium bicarbonate). The net inflammatory effects of Carrageenin was determined as the total inflammatory response minus the inflammatory effects of the vehicle. In the second series of experiments, the irritant injected into the mouse foot pad was a highly purified human and/or snake PLA2s. The anti- inflammatory effects of oligo-PGB in this model system are presented.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 28, 1988
- Accession Number
- ADA197373
Entities
People
- Richard C. Franson
- Roger M. Loria
- William Regelson
Organizations
- Virginia Commonwealth University