Pyridostigmine Induced Alterations in Rats: Impact of Body Weight and Nifedipine Pretreatment

Abstract

When rats were injected with pyridostigmine (PYR) based on a mg/kg dosage, lethality appeared to be greater than anticipated when 500g rats were used. Twenty-four hour survival was determined for groups of large and small rats. These animals received a sc injection of either Mestinon equivalent buffer, 1.8mg or 3.6mg PYR/kg body weight. Serum cholinesterase (ChE) levels were determined for similar doses. With PYR dosage based on mg/kg, small rats were significantly more resistant to PYR than large rats, and also had significantly higher control levels of serum ChE. Keywords: Pyridostigmine; Nifedipine; Cholinesterase; Mitochondria.

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Document Details

Document Type
Technical Report
Publication Date
Jun 02, 1988
Accession Number
ADA197493

Entities

People

  • Iris Castro
  • Michael Blaha
  • Patricia Daum
  • Wilbert D. Bowers Jr.

Organizations

  • United States Army Research Institute of Environmental Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Body Weight
  • Cell Physiological Processes
  • Cells
  • Diseases And Disorders
  • Electron Density
  • Electron Microscopy
  • Electrons
  • Heart
  • Laboratory Animals
  • Microscopy
  • Mitochondria
  • Muscle Cells
  • Muscles
  • Poisoning
  • Skeletal Muscle
  • Tissues

Fields of Study

  • Biology
  • Psychology

Readers

  • Neurotoxicology
  • Toxicology/Environmental Toxicology