Effect of Chlorpromazine on the Toxicity in Mice of the Venoms and Neurotoxins from Various Snakes

Abstract

I determined the efficacy of chlorpromazine with respect to reducing the toxicity in mice of Bungarus caeruleus venom, Bungarus multicinctus venom and its neurotoxic components alpha-bungarotoxin and beta-bungarotoxin, Crotalus durissus terrificus venom and its neurotoxic component crotoxin; and Oxyuranus scutellatus venom and its neurotoxic component taipoxin. Venom or toxin was administered followed immediately by injection of chlorpromazine. The effect of chlorpromazine on lethality caused by the venom or toxin was recorded 24 hr later. Chlorpromazine proved to be an effective antagonist of the toxicity of B. caeruleus venom, B. multicinctus venom, and beta-bungarotoxin without itself being overtly toxic. Chlorpromazine was also injected at different times both and after the injection of venom or toxin. Protection from lethality was maximal when chlorpromazine was administered immediately after injection of venom or toxin. Keywords: Snake venom, Toxins and antitoxins.

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Document Details

Document Type
Technical Report
Publication Date
Jul 26, 1988
Accession Number
ADA197986

Entities

People

  • Richard D. Crosland

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Biomedical Research
  • Chlorpromazine
  • Classification
  • Diseases And Disorders
  • Elements
  • Infectious Diseases
  • Lethal Dosage
  • Lethality
  • Neurotoxins
  • Polymorphonuclear Leukocytes
  • Security
  • Snake Bites
  • Toxicity
  • Toxins
  • Toxins And Antitoxins
  • Uranium Compounds

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