Circulatory and Hematological Effects of Liquid Propellant 1846 Following Oral Administration to Rats

Abstract

Hydroxylammonium nitrate (HAN), a major component of the liquid propellant 1846 (LP1846), has been reported to produce methemoglobinemia, Heinz body formation, and hypotension in rats. This study was conducted to define the relative sensitivity and reversibility of the methemoglobinemia, hypotension, and Heinz body formation following oral administration of LP1846 to male rats. Blood pressure was monitored before dosing and for 60 minutes following dosing. Blood samples for determining the presence of methemoglobin and identifying Heinz bodies were obtained at intervals until methemoglobin values returned to normal. Heinz bodies were present in all treated animals. These data suggest that the presence of elevated methemoglobin levels and/or Heinz bodies would be useful indices of occupational exposure to LP1846.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1988
Accession Number
ADA198046

Entities

People

  • Danley F. Brown
  • Don W. Korte Jr.
  • Gayle A. Orner

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Cardiovascular Physiological Phenomena
  • Catheters
  • Classification
  • Data Science
  • Indicator Dyes
  • Information Science
  • Intervals
  • Laboratory Animals
  • Liquid Propellants
  • Materials Laboratories
  • Methemoglobin
  • Propellants
  • Scientific Research
  • Standards
  • Statistical Analysis

Readers

  • Rocket Propulsion.
  • Toxicology/Environmental Toxicology