The Molecular Targets of Selected Organophosphorus Compounds at Nicotinic, Muscarinic, GABA, and Glutamate Synapases: Acute and Chronic Studies Including Prophylactic and Therapeutic Approaches
Abstract
Studies during the past year have been focused on: a) continuing the investigation of the organophosphorus compounds (OPs) on the chemosensitive receptors located at various synapses; b) attempting to discern the active sites of the receptor-ion channel complexes involved in activation, desensitization and blockade; c) establishing the concentration gradients for various noncompetitive antagonists for production of states of activation, inactivation and blockade of the receptor-channel macromolecule; d) delineating avenues of testing, in in vivo and in vitro conditions, new agents which will be proven effective in alleviation of symptomatology and intoxication produced by OPs; e) recommending an agent or combination of agents which will be prophylactically and therapeutically effective against OP intoxication. Keywords: Organophosphates, Cholinesterase, Organophosphorus agents, Acetylcholine, Nicotinic receptor-ion channel complex, Desensitization, Oximes, Irreversible cholinesterase inhibitors, Oximes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 10, 1987
- Accession Number
- ADA198049
Entities
People
- E. X. Albuquerque
Organizations
- University of Maryland School of Medicine