Teratology Studies of Lewisite and Sulfur Mustard Agents: Effects of Lewisite in Rats and Rabbits

Abstract

Lewisite, which is a prototype of one of two categories of vesicant war gases, functions by reacting with the sulfhydryl groups of proteins through its arsenic group. Since no information concerning the potential teratogenicity or developmental toxicity of lewisite was available, Pacific Northwest Laboratory, (PNL), under contract with USABRDL, conducted studies to evaluate maternal toxicity, intrauterine mortality and developmental toxicity in rats and rabbits following the administration of this agent by intragastric intubation. Keywords: Teratology; Chemical warfare.

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Document Details

Document Type
Technical Report
Publication Date
Dec 31, 1987
Accession Number
ADA198423

Entities

People

  • J. A. Cushing
  • L. B. Sasser
  • P. L. Hackett
  • R. L. Buschbom
  • R. L. Rommereim

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  • Battelle Memorial Institute

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  • Biomedical

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  • Analytical Chemistry
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