Primary Dermal Irritation Potential of Guanidine Nitrate in Rabbits

Abstract

The primary dermal irritation potential of guanidine nitrate was determined in male and female New Zealand White rabbits using a modified Draize method. The test compound was classified as a severe primary irritant with corrosive properties. Erythema, edema, and eschar formation (injuries in depth) were detected at 24, 48, and 72 hours after dosing. Irreversible skin damage was apparent at the time of sacrifice, 14 days after dosing. Keywords: Triple base propellants; Exposure physiology; Primary dermal irritation; Guanidine nitrate; Nitroguanidine; Munitions; Mammalian toxicology; Rabbits.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1988
Accession Number
ADA198495

Entities

People

  • Don W. Korte Jr.
  • Joy W. Bauserman
  • Yvonne C. Letellier

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Chemical Analysis
  • Classification
  • Computers
  • Databases
  • Guanidine Nitrates
  • Health
  • Health Services
  • Irritation
  • Materials
  • New Zealand
  • Nitroguanidine
  • Propellants
  • Quarantine
  • Toxicology
  • Triple Base Propellants
  • United States

Readers

  • Toxicology/Environmental Toxicology