External Factors, Produced by Growing Nerves, Trigger a Regenerative Response in a Non-Regenerative Central Nervous System: Purification and Mode of Action
Abstract
Mammalian central nervous system (CNS) neurons have a negligible post-traumatic regenerative capacity while the nerves of lower vertebrates, as well as the peripheral nervous system (PNS) of mammals regenerate spontaneously after injury. Studies carried out in our laboratory as well as in several other laboratories suggested that CNS neurons may have the intrinsic capacity to regenerate but fail to do so because they are surrounded by an inappropriate or inhospitable environment. We modulated the environment by the application of soluble substances originating from growing nerves (fish optic nerves regenerating after trauma or developing, neonatal rabbit optic nerves) in the form of media conditioned (CM) by such nerves implanted into injured optic nerves of adult rabbits. Last year we identified two components within the CM, apolipoprotein-A-I involving in scavenging lipid degradation products and a glial modulating factor(s) which effects glial cell behavior, as manifested by laminin production, thereby possibly circumventing one of the barriers for regeneration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1988
- Accession Number
- ADA198517
Entities
People
- Michal Schwartz
Organizations
- Weizmann Institute of Science