Mutagenic Potential of Nitroguanidine in the Drosophila melanogaster Sex-Linked Recessive Lethal Test

Abstract

Nitroguanidine, a primary component of U.S. Army triple-base propellants, was evaluated for mutagenic potential in the Drosophila melanogaster Sex-Linked Recessive Lethal test. Nitroguanidine was non-mutagenic following 72-hour feeding exposures to concentrations of nitroguanidine ranging from 2.08 micrograms/millimeter to 20.8 micrograms/millimeter. Keywords: Mutagenicity, Genetic toxicology, Sex-linked recess lethal assay, Drosophila melanogaster, Nitroguanidine.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1988
Accession Number
ADA198534

Entities

People

  • Don W. Korte Jr.
  • Lillie D. Witcher
  • Raj K. Gupta
  • Vilmar O. Villa

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biological Sciences
  • Biomedical Research
  • Cells
  • Chromosomes
  • Classification
  • Genetics
  • Health Services
  • Identification
  • Identification Systems
  • Propellants
  • Security
  • Toxicity
  • Toxicology
  • Triple Base Propellants
  • United States

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology
  • Biotechnology - Bioremediation