Characterization of Two (3H) Ketanserin Recognition Sites in Rat Striatum

Abstract

Two H(3) ketanserin recognition sites are present in the rat striatum. The high-affinity site is similar to the 5-hydroxytryptamine(2) (5- HT(2)) site previously characterized by various investigators. The low-affinity site has a unique pharmacologic specificity and is preferentially localized to rate striatum and septum. Conventional 5-HT(2) antagonists as well as 5-HT and 5-HT uptake inhibitors are ineffective at inhibiting H(3)-ketanserin binding to this low-affinity site. Also, chronic treatment with p-chlorophenylalanine, which depletes brain 5-HT, up regulates only the high-affinity site. Thus, in the striatum and septum, H(3) ketanserin labels a unique recognition site. This site has recently been shown to be associated with dopaminergic nerve endings and may regulate biogenic amine release. Keywords: Serotonin; 5- Hydroxytryptamine(2) receptors; Ketanserin; Recognition site; Reprints; Binding sites.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1987
Accession Number
ADA198633

Entities

People

  • B. L. Roth
  • D.-m. Chuang
  • S. Mclean
  • X.-z. Zhu

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acids
  • Amines
  • Biomedical Research
  • Brain
  • Central Nervous System
  • Cerebral Cortex
  • Chemistry
  • Data Analysis
  • Drug Abuse
  • Isotherms
  • Lysergic Acids
  • Materials
  • Near Infrared Radiation
  • Nervous System
  • Peripheral Nervous System
  • Regression Analysis
  • Serotonin Agents

Fields of Study

  • Biology

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