Testing of Experimental Compounds for Efficacy Against Leishmania

Abstract

A total of 82 compounds were studied in the primary visceral test system for suppressive activity against Leishmania donovani in golden hamsters. Thirty-two were noted to have some suppressive activity and 4 of these active compounds had activity greater than that of the reference compound, glucantime (Glucantime Index ranged from 2.62 to 14.18). Sinefungin was included among these highly active compounds.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1986
Accession Number
ADA198705

Entities

People

  • Virginia B. Waits
  • William L. Hanson
  • Willie L. Chapman Jr.

Organizations

  • University of Georgia

Tags

DTIC Thesaurus Topics

  • Animals
  • Antileishmanial Drugs
  • Biological Sciences
  • Body Weight
  • Cells
  • Chemotherapy
  • Clinical Trials
  • Databases
  • Diseases And Disorders
  • Infection
  • Infectious Diseases
  • Laboratory Animals
  • Leishmania
  • Leishmaniasis
  • Medical Personnel
  • Rodents
  • Therapy

Readers

  • Parasitology and Pharmacology of Malaria.