Receptor Binding and Membrane Transport of Botulinum Toxins.

Abstract

The goal of this research is to characterize the interaction of botulinum neurotoxin with membranes, and seeks to add to the field of study of protein/lipid interactions in general. A model system of study has been developed to define which portions of the botulinum toxin insert and/or interact with artificial liposomes in order to define 'membrane-active' portions of the molecule. This will enable a more defined study of the protein as it interacts with a bilayer through the use of protein and membrane probes to map the topography of the toxin in the membrane, and will also define possibly critical areas of the molecule which can be used as templates to produce artificial inhibitors of botulinum activity. (AW)

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1988
Accession Number
ADA198935

Entities

People

  • John R. Dankert

Organizations

  • University of Florida

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Amino Acids
  • Cells
  • Cells (Biology)
  • Cholesterol
  • Classification
  • Eukaryotes
  • Hormones
  • Hydrophobic Properties
  • Inhibitors
  • Lipids
  • Materials
  • Membrane Lipids
  • Molecular Weight
  • Molecules
  • Security
  • Synthetic Membranes

Readers

  • Molecular and Cellular Biochemistry
  • Theoretical Analysis.