Development of In Vitro Isolated Perfused Porcine Skin Flaps for Study of Percutaneous Absorption of Xenobiotics

Abstract

Interspecies comparisons of cutaneous anatomy and physiology suggest that the weanling pig is a suitable surrogate for human skin; however, very few investigations of percutaneous absorption phenomena have been conducted in pigs. This study examined the radiolabel excretion patterns after intravenous (IV) and topical administration of six 14C-labeled compounds in weanling Yorkshire sows. These data were required as a baseline to compare xenobiotic absorption in the isolated perfused procine skin flap (IPPSF) fully described in the first Annual Report (Riviere, J. E., Bowman, K. F., and Monteiro-Riviere, N. A., Development of In Vitro Isolated Perfused Porcine Skin Flaps for Study of Percutaneous Absorption of Xenobiotics, USAMRDC, DAMD17-84-C-4103, November 1, 1986). Keywords: Pig; Skin; Porcine; Integument; Absorption; Pharmacology; Toxicology.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1986
Accession Number
ADA198960

Entities

People

  • J. E. Riviere
  • K. F. Bowman
  • M. P. Carver
  • N. A. Monteiro-riviere

Organizations

  • North Carolina State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acids
  • Alcohols
  • Animals
  • Blood
  • Chemistry
  • Classification
  • Drug Therapy
  • Enzyme Kinetics
  • Laboratory Animals
  • Metabolism
  • North Carolina
  • Organic Acids
  • Pharmacology
  • Rodents
  • Security
  • Tissues
  • Veins

Readers

  • Toxicology/Environmental Toxicology
  • Trauma Surgery or Emergency Medicine.