Conference on Receptor-Based Biosensors (3rd) Held in Aberdeen Proving Ground, Maryland, September 1987
Abstract
Advances in biotechnologies of fermentation and genetic engineering have created the potential for the large-scale production of toxins, creating a new chemical and biological (CB) warfare threat of incredible diversity that existing reconnaissance, detection, and identification methods cannot meet. CB agents owe their extreme toxicity to selective interaction with biological recognition sites known generically as receptors, which are vital for cellular function. A novel, target-oriented strategy has evolved to exploit the fact that receptors are, by nature, extremely efficient detectors of CB agents. The issues are: could receptors, coupled with electronic microsensors, detect all known and unknown CB agents, and, if so, how many receptors would be required? The focus of this meeting is on a systems engineering approach to biosensor development. Specific topics discussed include production of receptors using molecular biological and hybridoma techniques, receptor immobilization and interaction with artificial supports, diverse microsensor technologies, and signal transduction and processing.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1988
- Accession Number
- ADA198966
Entities
People
- Darrel E. Menking
- James J. Valdes
- Mia Paterno
Organizations
- Edgewood Chemical Biological Center