Biopolymers: Protein and Nucleic Acids
Abstract
The work focuses on learning the principles that govern interactions between proteins and nucleic acids both DNA and RNA (specifically tRNA). With these principles as guides we are synthesizing peptides (of about 50 amino acids) that bind to specific regions of DNA. Various reactive functionalities are being attached to the synthetic peptides to generate reagents that cleave DNA specifically at the site to which the peptide binds. The work also involves biophysical studies of the protein/nucleic acid complexes in order to expand our understanding of the principles of protein binding to nucleic acids. Development of improved procedures for the chemical synthesis of peptides forms another important aspect of the program. Keywords: Molecule interactions; Synthesis chemistry; Protein-DNA binding; Peptide synthesis; DNA Cleavage; NMR of proteins and nucleic acids; tRNA Specificity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 15, 1988
- Accession Number
- ADA198994
Entities
People
- John H. Richards
- John N. Abelson
- Lee H. Hood
- Melvin I. Simon
- Peter B. Dervan
Organizations
- California Institute of Technology