Mutagenic Potential of Nitrosoguanidine in the Drosophila melanogaster Sex-Linked Recessive Lethal Test

Abstract

Nitrosoguanidine, an anticipated degradation product of nitroguanidine which in turn is a primary component of U.S. Army tripe-base propellants, was evaluated for mutagenic potential in the Drosophila melanogaster Sex-Linked Recessive Lethal test. Nitrosoguanidine was non- mutagenic following 72-hour feeding exposures to concentrations of nitrosoguanidine ranging from 5 mg/ml to 50 mg/ml. Keywords: Mutagenicity, Genetic toxicology.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1988
Accession Number
ADA199154

Entities

People

  • Don W. Korte Jr.
  • Raj K. Gupta
  • Vilmar O. Villa

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Animals
  • Biological Sciences
  • Biomedical Research
  • Cells
  • Chromosomes
  • Classification
  • Diptera
  • Drosophila
  • Genetics
  • Health Services
  • Identification Systems
  • Materials
  • Nitroguanidine
  • Nitroso Compounds
  • Propellants
  • Security
  • Triple Base Propellants

Readers

  • Agricultural Chemistry/Soil Science
  • Environmental Engineering
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology
  • Biotechnology - Bioremediation