Bioassay of Military Relevant Compounds for Carcinogenic Activity by the Strain A Mouse Lung Tumor Bioassay
Abstract
The Medical College of Ohio conducted studies to determine the carcinogenic potential of a series of dinitrotoluene compounds, diaminotoluenes, dyes, and other selected compounds for carcinogenic activity in the strain A mouse lung tumor bioassay. In most cases, a comparison was made of the carcinogenic potential of the chemicals following either intraperitoneal (i.p.) or oral (p.o., by gavage) administration. 2,4-Dinitrotoluene, 2,6- dinitrotoluene, a 2:1 mixture of 2,4-dinitro-toluene and 2,6-dinitrotoluene did not induce lung tumors in A/J mice at any of the three dose levels given, or by either route of administration. 2,3-Dinitrotoluene, 2,5-dinitrotoluene, 3,4- dinitrotoluene, 3,5-dinitrotoluene, and two dyes used in colored smoke grenades; i.e., C.I. Solvent Yellow 33 and a mixture of C.I. Solvent Green 3/C.I. Solvent Yellow 33 were also negative for lung tumor induction following i.p. administration. 2,6-Diaminotoluene, a metabolite of 2,6-dinitrotoluene, induced a significant (albeit marginal) increase in the lung tumor response when given i.p at a total dose of 375 mg/kg. After p.o. administration at the same dose, the compound produced an increase in the tumor response, but the increase was not significant. 2,4-Diaminotoluene was negative for lung tumor induction in strain A mice.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1985
- Accession Number
- ADA199188
Entities
People
- Gary D. Stoner
- Herman A. Schut
Organizations
- University of Toledo Medical Center