Primary Dermal Irritation Potential of Trimethylolethane Trinitrate (TMETN) in Rabbits

Abstract

The primary dermal irritation potential of trimethylolethane trinitrate (TMETN) was determined in male and female New Zealand White rabbits using a modified Draize method. The test compound was non-irritating. Very slight erythema was observed in 2 rabbits by 1/2 hour after dosing and in 4 rabbits at 24 hours after dosing. All rabbits had returned to normal by 48 hours after dosing. Neither edema nor any other recognizable skin reaction was detected at any time during the 14-day observation period. Keywords: Primary dermal irritation, Trimethylolethane trinitrate, TMETN, Mammalian toxicology, Rabbits, Munitions.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1986
Accession Number
ADA199381

Entities

People

  • Don W. Korte Jr.
  • Earl W. Morgan

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Animals
  • Bioengineering
  • Detectors
  • Irritation
  • Lagomorphs
  • Magnetic Resonance
  • Materials
  • New Zealand
  • Observation
  • Pharmacology
  • Physical Properties
  • Rodents
  • Skin Diseases
  • Toxicity
  • Toxicology
  • Triple Base Propellants

Fields of Study

  • Biology

Readers

  • Toxicology/Environmental Toxicology