Mechanism of Cytotoxicity of the AIDS (Acquired Immunodeficiency Syndrome) Virus, HTLV-III/LAV

Abstract

Understanding the mechanism of human immunodeficiency virus (HIV) type 1 replication and cytopathicity are critical to determining the pathogenesis and treatment of the acquired immunodeficiency syndrome (AIDS) and associated diseases. Studies of related viruses, (SIV) and HIV-2, complement these studies and allow additional animal model systems for testing hypotheses. We have studied three aspects of HIV pathogenesis. First, a mutagenic analysis of HIV-1, SIV, and HIV-2 genes has been performed to decipher their role in replication and cytopathic activity. Second, immunopathogenetic consequences have been studied with respect to the characterization of lymphotoxin-like molecule which is secreted by HIV-1 infected cells. Third, the structure and function of HIV-1 env variation has been studied in a clustered outbreak of HIV- 1 infection to elucidate the role of envelope alterations in immune evasion and tissue tropism. Keywords: Genetics, Mutation.

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Document Details

Document Type
Technical Report
Publication Date
Apr 21, 1988
Accession Number
ADA199508

Entities

People

  • Lee Ratner

Organizations

  • Washington University in St. Louis

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquired Immune Deficiency Syndrome
  • Amino Acids
  • Blood
  • Brain
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Genetic Code
  • Genetics
  • Immune System
  • Infection
  • Molecules
  • Proteins
  • Virion
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Immunology
  • Molecular and genetic basis of cancer.
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology