Characterization of the Ptychodiscus brevis Polyether Neurotoxin Binding Component in Excitable Membranes

Abstract

The research is aimed at characterization of the binding site for Ptychodiscus brevis neurotoxin PbTx-3 (formerly known as T17) in nerve tissues, specifically in rat brain synaptosomes. The polyether lipid-soluble toxins isolated from the marine dinoflagellate Ptychodiscus brevis (formerly Gymnodinium breve) bind to a unique site, Site V, associated with the voltage- sensitive sodium channel probe for binding at Site V, dissociation constants and binding maxima have been determined in rat, fish, and turtle brain synaptosomes. Keywords: Binding sites; Active sites; Membranes biology; Sodium channels; Brevetoxins; Toxins.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 31, 1988
Accession Number
ADA199525

Entities

People

  • Daniel G. Baden
  • Thomas J. Mende

Organizations

  • University of Miami

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Albumins
  • Alcohols
  • Animals
  • Biomedical Research
  • Chemistry
  • Competition
  • Dissociation
  • Equations
  • Inhibition
  • Laboratory Animals
  • Membrane Potentials
  • Membranes
  • Molecules
  • Personality
  • Polyethers
  • Proteins
  • Tissues

Fields of Study

  • Biology

Readers

  • Microbial Pathology
  • Neuroscience