Developmental Toxicology of Methylphosphonic Difluoride (DF)

Abstract

The teratogenicity of vaporized methlyphosphonic difluoride (DF) was investigated using the rat and rabbit as the experimental models. Pregnant rats and rabbits were exposed. Dams and does exposed exhibited nasal exudate and raspy breathing. These dams also had significantly lower body weights on the last three of four weighings. There were, however, no differences between the control litters and the DF-exposed litters for the parameters: litter number, mean body weight, mean crown-rump length, visceral or skeletal malformations. It was concluded that DF is not teratogenic in the rat or rabbit by the inhalation route at the concentrations tested. Keywords: Fetus; Teratogenic compounds; Gestation; Organogenesis; Pregnant.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1988
Accession Number
ADA199597

Entities

People

  • Dale H. Heitkamp
  • David C. Burnett
  • James H. Manthei
  • Roger J. Hilaski
  • William C. Starke

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DTIC Thesaurus Topics

  • Abnormalities
  • Abstracts
  • Air Pressure
  • Animals
  • Body Weight
  • Brain
  • Classification
  • Experimental Design
  • Heart
  • Laboratory Animals
  • Osteogenesis
  • Security
  • Spinal Cord
  • Stainless Steel
  • Technical Information Centers
  • Teratology
  • Water

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  • Toxicology/Environmental Toxicology