Fiber Optic Microsensor for Receptor-Based Assays

Abstract

This project established the feasibility of adapting fiber optic fluorescence immunoassay (FFIA) instrument as a pocket-sized microsensor for rapid receptor-based assays. The instrument, with its light-emitting diode (LED) source and solid state detector, was demonstrated to satisfy projected sensitivity requirement for a receptor-base assay device. An aqueous solution of fluorescent tag was successfully detected at a noise equivalent concentration (NEC) in the subpicomolar range. In actual practice, system sensitivity will be limited by biological factors such as the ability of the receptor coating to specifically bind at such low concentrations. Keywords: Microsensors; Receptor; Optical wave.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1988
Accession Number
ADA199757

Entities

People

  • James J. Valdes
  • Myron J. Block
  • Thomas R. Glass

Tags

Communities of Interest

  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Aqueous Solutions
  • Biological Factors
  • Classification
  • Computers
  • Contracts
  • Detection
  • Detectors
  • Diodes
  • Fluorescence
  • Light Emitting Diodes
  • Light Sources
  • Medical Personnel
  • Microsensors
  • Security
  • Sensitivity
  • Spectra
  • Test And Evaluation

Readers

  • Agricultural Chemistry/Soil Science
  • Molecular Genetics
  • Optical Fiber Sensing and Electromagnetic Propagation.