An Experimental Brain Missile Wound: Ascertaining Pathophysiology and Evaluating Treatments to Lower Mortality and Morbidity
Abstract
We have developed a laboratory model for painlessly creating a uniform brain wound in anesthetized cats and have studied blood flow in the brain before wounding and 1,30,45 and 90 minutes thereafter. By means of microspheres we have made these blood flow determinations in 35 distinct brain regions including the brain immediately adjacent to the missile track. Blood flow transiently increased one minute after wounding where the test missile struck the brain and in contracoup areas. This increased flow resulted from loss of cerebral autoregulation and concomitant systemic arterial hypertension. Thirty minutes after wounding blood flow transiently increased about the wound track itself. A mild decrease in regional cerebral blood flow transiently increased about the wound track itself. Blood flow was unaffected in most brain areas. Keywords: Experimental brain wounding; Regional cerebral blood flow after wounding.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 21, 1987
- Accession Number
- ADA199957
Entities
People
- Dan Torbati
- H. C. Mckowen
- J. B. Farrell
- Joseph Soblosky
- June Davidson
- Michael E. Carey
Organizations
- LSU Health Sciences Center New Orleans