Analysis of the Human T Cell Response to HTLV-III (AIDS)

Abstract

Acquired Immune Deficiency Syndrome is marked by a collapse in immune responses, particularly those mediated by thymus-derived (T) lymphocytes. Nevertheless, the presence of antibodies to the AIDS virus (HIV) indicates the presence of virus specific T cells. In the course of attempting to expand virus specific T cells from HIV seropositive patients, we have determined that the immunomodulator interferon is capable of containing T cell responses in patients with AIDS. These effects occur for T cells responsive to both mitogens and antigens, but only in moderately advanced (no in far advanced) disease. Keywords: Vaccine development, Cellular immunity, Human immunodeficiency virus, Virology, Monoclonal antibody, Anti-idiotype antibody, Lab animals, Rats, Volunteers. AIDS, Acquired Immune Deficiency.

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Document Details

Document Type
Technical Report
Publication Date
Jun 30, 1988
Accession Number
ADA200003

Entities

People

  • Robert W. Finberg

Organizations

  • Dana–Farber Cancer Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Antibodies
  • Antigens
  • Bacterial Infections
  • Blood
  • Blood Cells
  • Cells
  • Diseases And Disorders
  • Hiv Infections
  • Infection
  • Interferon
  • Leukocytes
  • Lymphocytes
  • Microorganisms
  • Molecules
  • Proteins
  • Viruses

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech