Validation and Application of Pharmacokinetic Models for Interspecies Extrapolations in Toxicity Risk Assessments of Volatile Organics
Abstract
In pursuit of the goal of establishing a scientific basis for the interspecies extrapolation of pharmacokinetic data in health risk assessments, a series of studies have been conducted involving pharmacokinetic determinations in rats (to be followed later in dogs) to several aliphatic halocarbons. Direct measurements of the uptake and elimination of halocarbon in the blood and exhaled breath of rats have been completed during and following inhalation exposures to trichloroethylene (TCE),trichloroethane (TRI), and dichlorethylene (DCE). Two manuscripts have been completed for publication in peer-reviewed journals on the work with inhaled TCE and TRI. pharmacokinetic determinations have also been made in studies of the ingestion of TCE, TRI, and DCE. Keywords: Physiologically-based pharmacokinetic model, Saturable metabolism, Respiratory elimination, Halocarbon inhalation exposure, Halocarbon oral exposure, Interspecies extrapolations, Pharmacokinetics, 1,1,1-Trichloroethane, 1,1- Dichloroethylene.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 30, 1988
- Accession Number
- ADA200034
Entities
People
- Cham E. Dallas
- James Gallo
- James V. Bruckner
- Muralidhara Srinivasa
- Ramanathan Raghupathy
Organizations
- University of Georgia