Development of Medical Adjunctive Treatment for Acute Penetrating Head Injury

Abstract

The overall objective of the Army Penetrating Head injury Project (APHIP) is to establish a collaborative multicenter system that can conduct rigorous, standardized scientific clinical trails in head injured patients; and then to use that system to study the pathophysiology and behavioral consequences of head injury and to develop and test promising new therapies and management strategies in such patients. A promising new drug, PEG-Superoxide Dismutase (PEG-SOD) has been selected for the initial therapeutic trials. Ancillary studies include a national survey of over 3000 neurosurgeons regarding management of penetrating head injury (PHI). This has now been completed with over 35% response rate and shows wide variability and general lack of consensus on the management of PHI; a manuscript has been prepared. Other studies include collaborative development of a rat model of head injury for biochemical studies (protocol completed, pending USUHS approval), and continued analysis of long term PHI outcome data generated in the Vietnam Head injury Study (VHIS).

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1988
Accession Number
ADA200093

Entities

People

  • Andres M. Salazar

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Arteries
  • Brain
  • Cardiovascular Physiological Phenomena
  • Chemical Synthesis
  • Drug Abuse
  • Health Services
  • Medical Personnel
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Neurotrauma and Rehabilitation Medicine.