The Effects of Hydrazines on Neuronal Excitability
Abstract
Hydrazines are toxic compounds with military and industrial applications including use as missile propellants for aircraft (i.e. the F-16 and space vehicles). Recurrent exposure from routine storage, use, and disposal hydrazines makes their toxic effects on the nervous system important. Exposure to hydrazine can result in status epilepticus and eventual respiratory collapse. Acute exposure can produce repeated tonic-clonic seizures in both animal and man. This project has continued to direct its effort in understanding the molecular mechanism by which hydrazines may produce their neuronal excitatory effects. Our investigation focuses on the effects of hydrazine on electrophysiological properties of identified neurons in the invertebrate Hermissenda Crassicornis. We have documented that hydrazines increase neuronal excitability in the LP-1 neuron of this nudibranch mollusc. Hydrazines also increase the rate of sustained repetitive firing in this system. We will study molecular mechanism mediating the effects of hydrazine on increased neuronal firing in isolated neurons. Specific anticonvulsant drugs may have potential benefit in blocking the excitable effects of hydrazine on neuronal activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 10, 1988
- Accession Number
- ADA200199
Entities
People
- Robert J. Delorenzo
Organizations
- Virginia Commonwealth University School of Medicine