Mipafox as a Substrate for Rangia-DFPase

Abstract

The effect of mipafox (N,N'-diisopropylphosphordiamidofluoridate) on the DFPase activity of clam digestive gland was investigated. An increasing trend in hydrolysis rates resulted where mipafox activity < DFP activity < DFP with mipafox activity. Mipafox is a known inhibitor of DFPase from hog's kidney and Tetrahymena thermophila but does not inhibit squid-type DFPase. The observed additive effect of DFP with mipafox hydrolysis rates appears, in this case, to be a unique characteristic of Rangia-extract. Keywords: Amides; Fluorine compounds; Organic fluorine compounds.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1988
Accession Number
ADA200284

Entities

People

  • Nancy A. Chester
  • Robert S. Anderson
  • Wayne G. Landis

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  • Edgewood Chemical Biological Center

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  • Fluorides
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