Regulation of Voltage-Dependent Channel Function
Abstract
Using fluorescent photobleaching recovery techniques, it was found that the diffusion coefficient of lipid probes within neuronal membranes of Aplysia were temperature insensitive. However, the percent of the probe free to migrate changed as a function of temperature. The temperature sensitivity of A- currents were much greater than those of calcium currents in the same cell. Among the multiple classes of A-current channels some showed significant changes in acute temperature sensitivity as a result of temperature history of the animal while others exhibited no change. The A-current channels some showed significant changes in acute temperature sensitivity as a result of temperature history of te animal while others exhibited no change. The was absent at low temperatures regardless of the rearing temperature of the animal, but grew significantly at temperatures warmer than those at which the animals were raised. It is hypothesized that this A-current acts to inhibit neuronal discharge at high rates during warming.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1988
- Accession Number
- ADA200375
Entities
People
- Steven N. Treistman