Lassa Fever Immune Plasma
Abstract
During the year 358 units of Lassa Fever Immune Plasma were obtained by plasmapheresis. Of these, 180 were forwarded to the US Army Medical Research Institute of Infectious Diseases (USAMRIID). Most will likely be used there in the production of Lassa Fever Immune Globulin (LFIG). LFIG will be a relatively stable product of known potency for the treatment of LF. Attempts to diagnose LF continued. The serological diagnosis of LF is made by seroconversion or a four- fold rise in the titer of indirect fluorescent antibody (IFA). Possible LF (PLF) is diagnosed by an IFS titer of 1:64 in a patient with an illness compatible with LF. At CLH 32 cases of LF and 11 of PLF were found; there were 27 and 25 cases, respectively, at PH. A case of PLF at Kolahun Hospital in the Liberian Northwest and one LF at ELWA hospital near the coast were the first active cases to be identified at these sites. A clinical association of LF with icteric hepatitis, and the impression that LF at PH has been more severe and more contagious recently than in the past deserve further virological study. Keywords: Lassa virus, Immunotherapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 31, 1988
- Accession Number
- ADA200922
Entities
People
- John D. Frame
Organizations
- Columbia University