Aerosol Transmission of Hantaan and Related Viruses to Laboratory Rats

Abstract

Hantaan (HTN), Seoul (SEO), and Puumala (PUU) viruses are members of the family Bunyaviridae, in the proposed genus Hantavirus. They are responsible for human disease ranging in severity from subclinical to hemorrhagic disorders collectively referred to as hemorrhagic fever with renal syndrome (HFRS). Natural hosts for HTN, PUU, and SEO viruses are striped field mice, Apodemus agrarius, bank voles, Clethrionomys glareolus, and domestic rats, Rattus norvegicus, respectively. Hantaan, Seoul, and Puumala viruses were transmitted to 12-16-week-old female Wistar Rattus norvegicus by inhalation. The rodent infectious dose for each virus by intramuscular inoculation and by inhalation was determined, as was the infectious dose for Vero E-6 cells by direct plaque assay. Reprints.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1988
Accession Number
ADA201147

Entities

People

  • Cynthia A. Rossi
  • Edward H. Stephenson
  • Edwin O. Nuzum
  • James W. Leduc

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Antibodies
  • Arboviruses
  • Barometric Pressure
  • Cells
  • Coinfection
  • Computer Science
  • Diseases And Disorders
  • Drug Abuse
  • Experimental Design
  • Hematologic Diseases
  • Infection
  • Laboratory Animals
  • Statistical Analysis
  • United States
  • Viruses
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Virology (or Medical Virology).