Effect of Radiofrequency Radiation on mRNA Expression in Cultured Rodent Cells
Abstract
Radiofrequency radiation (RFR) has been reported to induce adverse effects in biological systems, such as teratogenic and embryo lethal effects in mammals particularly during exposures producing significant hyperthermia 1. Other studies have implicated microwave exposure with causing changes in chromosome number 2 and structure 3, formation of cataracts in humans 4,5,6, rabbits 7,8,9,10,11 and dogs 12 and promoting malignant tumor formation in rats 13, as well as increasing tumor production and leukemias 14,15. In addition, microwave exposures have been reported to change the structure of purified double-stranded plasmid DNA, causing it to become nicked and increasing the proportion of relaxed to super coiled molecules 16. In view of these reports of changes at different levels of cellular function and structure of mammalian systems to microwaves, we asked ourselves if changes at the level of mRNA expression could be detected after microwave exposure of cultured rodent cells. We chose to look at the mRNA expression of certain oncogenes known to show elevated levels during cell replication, at the heat shock proteins, which are known to respond to stresses other than heat 17 and at the long terminal repeat (LTR) region of mouse mammary tumor virus in four rodent cell lines. Keywords: Reprints, Radiation effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1988
- Accession Number
- ADA201254
Entities
People
- Jill E. Parker
- Johnathan L. Kiel
- Wendell D. Winters
Organizations
- University of Texas Health Science Center at San Antonio