Testing of Compounds for Efficacy Against Schistosomiasis
Abstract
A new topical antipenetrant (TAP) was tested in animal test model systems for prevention of penetration of skin by schistosome infective larva (cercariae). The formulation provided complete protection of monkey skin when applied at -1 and -3 days before exposure to Schistosoma mansoni cercariae. When the formulation was applied at -7 days before exposure of monkey skin to S. mansoni, two of four monkeys were completely protected. The formulation was completely protective against invasion of hamster skin by S. mansoni and S. haematobium at -1 day but not at -3 or -7 days before exposure to cercariae. The formulation was not protective against skin invasion by S. japonicum cercariae. When the new formulation was applied simultaneously to skin with a anti-arthopod repellant, no interaction between the two compounds was observed. A total of nine candidate compounds were tested for oral prophylactic activity in the mouse test model system. Low levels of protection were obtained which varied from animal to animal. No complete protection was obtained. These compounds are not recommended for further evaluation as prophylactic candidate drugs. Keywords: Antipenetrant; Antischistosomal drug; Cercariae; Drug resistant; Prophylactic.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 25, 1988
- Accession Number
- ADA201617
Entities
People
- John I. Bruce