Correlation of Immunomodulatory and Therapeutic Activities of Interferon and Interferon Inducers in Metastatic Disease

Abstract

The mechanism of therapeutic activity of recombinant murine interferon-gamma (rMu IFN-gamma) and the IFN inducer polyinosinic-polycytidylic acid solubilized with poly-L-lysine in carboxy methyl cellulose (pICLC) in treating metastatic disease was investigated by comparing effector cell augmentation with therapeutic activity in mice bearing experimental lung metastases (B16-BL6 melanoma). Effector cell functions in spleen, peripheral blood, and lung (the organ with tumor) were tested after 1 adn 3 weeks of rMu IFN gamma or pICLC administration (intravenous, three times a week). In these studies, natural killer (NK), lymphokine-activated killer (LAK), cytolytic T lymphocytes (CTL) (against specific and nonspecific targets), and macrophage tumoricidal and tumoristatic activities were measured. Reprints.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1988
Accession Number
ADA201658

Entities

People

  • Hamblin Phillips
  • Henry R. Tribble
  • James E. Talmadge
  • Mark Schneider
  • Paul L. Black
  • Robin Pennington

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Biological Factors
  • Blood
  • Carcinoma
  • Cell Line
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Interferon
  • Lymphatic System
  • Lymphocytes
  • Macrophages
  • Neoplasms
  • Proteins
  • Research Facilities
  • Statistical Analysis
  • T Lymphocytes

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Oncology (Cancer Research).