Leishmania braziliensis panamensis: Increased Infectivity Resulting from Heat Shock

Abstract

Promastigotes of Leishmania braziliensis panamensis were subject to a heat shock transformation yielding an amastigote-like stage. During the process of conversion, the heat-induced differentiating form displayed an increase in infectivity (as determined by lesion size) accompanied by a total protein composition unlike that of the promastigote and a morphology resembling that of the amastigote. These biological/functional changes may be related to an involvement of a heat shock response in the differentiation of leishmania, thus having important implications in the development of prevention and treatment stratagems. Keywords: Hemoflagellate; Heat-induced differentiating form; Dulbecco's phosphate-buffered saline (PBS); Sodium dodecyl sulfate (SDS); Polyacrylamide gel electrophoresis (PAGE); Reprints.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1988
Accession Number
ADA201767

Entities

People

  • John G. Olenick
  • Ruth Wolff
  • Ruthann M. Smejkal

Organizations

  • Walter Reed Army Institute of Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Antigens
  • Bacteria
  • Biochemistry
  • Cells
  • Chemical Analysis
  • Chemistry
  • Environment
  • High Temperature
  • Infection
  • Infectious Diseases
  • Leishmania
  • Parasites
  • Parasitology
  • Protozoa
  • Security

Fields of Study

  • Biology

Readers

  • Infectious Disease/Epidemiology
  • Molecular and Cellular Biochemistry
  • Thin Film Deposition Science.