Ocular Irritation Evaluation with Eye Wash Regimen of Liquid Propellant 1846
Abstract
LP1846 is a liquid propellant under development by the U.S. Army for potential use in a 155-mm self-propelled howitzer. The purpose of this study was to determine whether LP1846 is an ocular irritant, and if so, whether flushing the eye with water 10 seconds or 30 seconds after exposure will reduce the ocular toxicity. The compound was tested in the laboratory rabbit. The result of this study indicate that LP1846 is an ocular irritant in accordance with test criteria of the Environmental Protection Agency. Observations included conjunctival redness, chemosis, iritis, corneal opacities, and neovascularization of the cornea. All lesions were reversible except for the neovascularization. Washing the eye at 30 seconds alleviated the conjunctival and iritic symptoms and prevented the development of corneal lesions. Immediate washing at 10 seconds was even more successful at alleviating the symptoms. However, even after washing, the ocular irritation potential of LP1846 was sufficient to produce an irritant response according to test criteria. Liquid propellant, LP1846, Rabbit, HAN, TEAN, Nitrates.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1988
- Accession Number
- ADA201799
Entities
People
- Don W. Korte Jr.
- James D. Justus
Organizations
- Letterman Army Hospital