Mutagenic Potential of Hydroxylamine Hydrochloride in the Ames Salmonella/Mammalian Microsome Mutagenicity Test.
Abstract
The mutagenic potential of HYDROXYLAMINE HYDROCHLORIDE (WR 740) was assessed in the Ames Salmonella/Mammalian Microsome Mutagenicity Test. Tester strains TA97, TA98, TA100, TA102, TA1535, TA1537, and TA1538 were exposed to doses ranging from 0.2 mg/plate to 8.2 x 10 to the minus 4 power mg/plate. In this test, HYDROXYLAMINE HYDROCHLORIDE produced a relatively high reversion rate at 2.5 x 10 to the minus 3 power mg/plate and 8.2 x 10 to the minus 4 power mg/plate in tester strain TA97, compared with the control (spontaneous revertant) plates. However, the spontaneous reversion rate was substantially lower than normally reported for TA97. HYDROXYLAMINE HYDROCHLORIDE also produced a relatively high reversion rate at .2 mg/plate and .06 6 mg/plate in tester strain TA1535. No mutagenic responses were observed for strains TA98, TA100, TA102, TA1537, and TA1538. A confirmatory test was conducted with strains TA97 and Ta1535. Mutagenicity, Genetic toxicology, ames test, HYDROXYLAMINE HYDROCHLORIDE. (jes)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1988
- Accession Number
- ADA201800
Entities
People
- Don W. Korte Jr.
- John W. Harbell
- Steven K. Sano
Organizations
- Letterman Army Hospital