Effects of Pharmacologic Intervention on Oxygenation, Lung Water and Protein Leak in the Pseudomonas ARDS Porcine Model

Abstract

The adult respiratory distress syndrome is a condition which occurs as a result of both direct and indirect pulmonary injury. The mortality rate for the syndrome which may affect previously fit patients is over 50% and higher where sepsis predominates. This mortality, despite modern techniques in intensive care, has hardly changed in 20 years. At the cellular level, the lung injury is due to damage of the alveolar capillary membrane by various circulating elements of the blood, most notably neutrophils. Thes neutrophils become 'activated' when they come in contact with a soluble or phagocytic stimulus, break down and release many inflammatory mediators.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1988
Accession Number
ADA201816

Entities

People

  • Harvey J. Sugerman
  • James L. Tatum
  • Jerry Hirsch
  • Karl Byrne

Organizations

  • Virginia Commonwealth University School of Medicine

Tags

DTIC Thesaurus Topics

  • Acute Respiratory Distress Syndrome
  • Airway Management
  • Arteries
  • Blood
  • Blood Coagulation Factors
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cells
  • Chemistry
  • Drug Therapy
  • Health Services
  • Lung Diseases
  • Respiratory Physiological Phenomena
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Systems Analysis and Design