Biological Applications and Effects of Optical Masers
Abstract
Threshold radiant exposures for retinal damage in 3 macaque monkeys are given for exposures of 0.5, 0.125 and 0.016 seconds duration to laser wavelengths 514.5 and 488 nm. Intravitreal injections of 5x.00005 gm of Cu-Zn Sod were toxic to cornea, lens and retina of the rhesus monkey after a radiant exposure of 33 j/sq.cm. of 440 nm light . No further experiments with SOd are contemplated. Similar experiments with catalase will be tried during the first quarter of the second contract year. The effect of oxygen on retinal toxicity during exposure to wave-lengths 540 , 640 and 840 nm were delayed by the untimely death of Dr. Millen , our consultant on anesthesiology and oxygen administration. Arrangements have been made to activate this program during the second contract year. Threshold data on 40 microsecond pulse trains cannot be obtained until the acoustic modulator can be incorporated into the Ar-Kr laser which was used during the contract year to produce exposures less than 1 second to 514.5 and 488 nm laser lines. Data on PRF's of 10 and 100 KHz and 1, 10 and 20 MHz will be obtained during the second contract year. The long-term experiment on cataractogenesis on 2 rhesus monkeys exposed to a near UV spectrum (330-420 nm) has been completed. Laser radiation; Optics; Monkeys; Histopathology; Safety standard.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 29, 1988
- Accession Number
- ADA201834
Entities
People
- Dupont Guerry Iii
- Harold A. Mueller
- R. K. Guerry
- Stephan F. Cleary
- William T. Ham Jr.
Organizations
- Virginia Commonwealth University School of Medicine