Pharmacological Protection of the Retina against Damaging Laser Exposures: A Feasibility Study
Abstract
Light damage to ocular tissues may occur through at least three mechanisms -- thermal, photochemical, or mechanical (photoacoustic) stress. These stress mechanisms may act singly, or in combination, depending on the intensity, wavelength, and temporal parameters of the damaging light exposure. Because some of these mechanisms involve biochemical intermediates, the possibility exists that appropriate pharmacological therapy might limit the extent of retinal light damage. This investigation determined the degree to which pharmacological pretreatments could protect a model retina against laser light damage. Five agents were examined for protective activity: an anti-inflammatory steroid hormone (dexamethasone); three antioxidants (3-aminotyrosine, vitamins C AND E); and a chelating agent (EGTA). Antioxidant; Laser; Light damage; Protection; Rabbit; Retina.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1988
- Accession Number
- ADA201898
Entities
People
- Randolph D. Glickman
- Robert M. Cartledge
- William R. Elliott Iii